UnlabelledTransforming growth factor beta (TGFβ) proteins are multitasking cytokines, in which high levels at tumor sites generally correlate with poor prognosis in human patients with cancer. Previously, it was reported that TGFβ downregulates the expression of ataxia telangiectasia-mutated (ATM) and mutS homolog 2 (MSH2) in breast cancer cells through an miRNA-mediated mechanism. In this study, expression of a panel of DNA-repair genes was examined, identifying breast cancer 1, early onset (BRCA1) as a target downregulated by TGFβ through the miR181 family. Correlations between the expression levels of TGFβ1 and the miR181/BRCA1 axis were observed in primary breast tumor specimens. By downregulating BRCA1, ATM, and MSH2, TGFβ orchestrates...
Breast cancer (BC) is potentially life-threatening malignancy that still causes high mortality among...
Background Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, s...
Previous studies have suggested that TGF-β functions as a tumor promoter in metastatic, mesenchymal-...
TRANSFORMING GROWTH FACTOR beta (TGFb) DOWNREGULATES HOMOLOGOUS RECOMBINATION REPAIR GENES AND INCRE...
The TGF-β, a tumor suppressive cytokine in normal cells, is abused in cancer to promote the malignan...
The transforming growth factor β (TGF-β), a tumor suppressive cytokine in normal cells, is abused in...
Even though a cadre of agents that inhibit transforming growth factor β (TGFβ) is being tested in ca...
Maintenance of mammary functional capacity during cycles of proliferation and regression depends on ...
Recent studies indicate that a subset of cancer cells possessing stem cell properties, referred to a...
Recent studies indicate that a subset of cancer cells possessing stem cell properties, referred to a...
Abstract Background Transforming growth factor-β (TGFβ) plays an important role in late-stage carcin...
We present an integromic analysis of gene alterations that modulate transforming growth factor β (TG...
Several members of the Poly(ADP-ribose) polymerase (PARP) family are essential regulators of genome ...
Breast cancer is the most common cancer in women worldwide. The tumor microenvironment contributes t...
Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tum...
Breast cancer (BC) is potentially life-threatening malignancy that still causes high mortality among...
Background Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, s...
Previous studies have suggested that TGF-β functions as a tumor promoter in metastatic, mesenchymal-...
TRANSFORMING GROWTH FACTOR beta (TGFb) DOWNREGULATES HOMOLOGOUS RECOMBINATION REPAIR GENES AND INCRE...
The TGF-β, a tumor suppressive cytokine in normal cells, is abused in cancer to promote the malignan...
The transforming growth factor β (TGF-β), a tumor suppressive cytokine in normal cells, is abused in...
Even though a cadre of agents that inhibit transforming growth factor β (TGFβ) is being tested in ca...
Maintenance of mammary functional capacity during cycles of proliferation and regression depends on ...
Recent studies indicate that a subset of cancer cells possessing stem cell properties, referred to a...
Recent studies indicate that a subset of cancer cells possessing stem cell properties, referred to a...
Abstract Background Transforming growth factor-β (TGFβ) plays an important role in late-stage carcin...
We present an integromic analysis of gene alterations that modulate transforming growth factor β (TG...
Several members of the Poly(ADP-ribose) polymerase (PARP) family are essential regulators of genome ...
Breast cancer is the most common cancer in women worldwide. The tumor microenvironment contributes t...
Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tum...
Breast cancer (BC) is potentially life-threatening malignancy that still causes high mortality among...
Background Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, s...
Previous studies have suggested that TGF-β functions as a tumor promoter in metastatic, mesenchymal-...